(a1/2) Except in the case of a pharmacy, wholesale druggist or outsourcing facility, every person with a principal place of business located in the commonwealth who is engaged in the manufacture or distribution of controlled substances through a contract with a manufacturing organization shall, upon payment of a fee, the amount of which shall be determined annually by the commissioner of administration and finance under the provision of section three B of chapter seven, register with the commissioner of public health, in accordance with his regulations, said registration to be effective for one year from the date of issuance.
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